Scopus indexed journals, updated list - sportbukmeker.com
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Maria completed a four year law degree at one of the top law schools in Romania, University of Alexandru Ioan Cuza, Iasi, and graduated with a 1st class Honours degree in Law. In she received a Master of Laws LL. Maria works closely with the senior solicitors and partners in numerous high value cases including fatal claims and cases with a foreign jurisdictional element. In her spare time, Maria enjoys sports activities, going to the cinema and seizing every opportunity to travel and encounter new people and cultures.
Discovery of potent and selective bromodomain inhibitors by high-throughput fragment docking. In the past three years, we have identified inhibitors for six human bromodomains, protein modules that bind acetylated histone tails. In the case of the CREBBP bromodomain, optimization of the initial hits by chemical synthesis of derivatives has resulted in several low-nanomolar binders with favorable ligand efficiency and selectivity against other bromodomains. Thus, the screening of fragment libraries by docking is very efficient 24, molecules in a day on a commodity desktop and the hit rate, i. Integer Linear Programming ILP is a very powerful technique for the solution of hard optimization problems.